Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Chemodex
Hydrocortisone
As low as
45
CHF
CHF 45.00
In stock
Only %1 left
CDX-H0269-G0011 gCHF 45.00
CDX-H0269-G0055 gCHF 103.00
CDX-H0269-G02525 gCHF 309.00
NEW
| Product Details | |
|---|---|
| Synonyms | 11β17α 21-Trihydroxypregn-4-ene-3,20-dione; Cortisol; Dihydrocostisone; NSC 10483; Kendall's compound F; Reichstein's substance M |
| Product Type | Chemical |
| Properties | |
| Formula | C21H30O5 |
| MW | 362.46 |
| CAS | 50-23-7 |
| RTECS | GM8925000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (20mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | JYGXADMDTFJGBT-VWUMJDOOSA-N |
| Smiles | O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Hydrocortisone is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). Hydrocortisone has three times the anti-inflammatory potency of corticosterone but much lower Na+ retention potency. It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor. Hydrocortisone plays a role in the regulation of metabolism, electrolyte balance, water balance, and the body's stress response. Hydrocortisone production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson's disease. It has been utilized in research to investigate the impact of inflammation and stress on cellular processes.
Product References
(1) D.T. Matulich, et al.; J. Clin. Endocrinol. Metab. 43, 1170 (1976) | (2) P.E. Stokes; Eur. Neuropsychopharmacol. 5, 77 (1995) | (3) F.P. Varghese & E.S. Brown; Prim. Care Companion. J. Clin. Psychiatry 3, 151 (2001) | (4) M. Quinkler & P.M. Stewart; J. Clin. Endocrinol. Metab. 88, 2384 (2003) | (5) J. Nijm & L. Jonasson; Ann. Med. 41, 224 (2009) | (6) S. Paredes & L. Ribeiro; Rev. Assoc. Med. Bras. 60, 84 (2014) | (7) D.J. van Wamelen, et al.; Int. Rev. Neurobiol. 152, 131 (2020)