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Chemodex
R-3-Hydroxyisobutyric acid sodium salt
162
CHF
CHF 162.00
In stock
CDX-H0291-M100100 mgCHF 162.00
| Product Details | |
|---|---|
| Synonyms | (R)-β-Hydroxyisobutyric acid sodium salt; (R)-3-Hydroxy-2-methylpropionic acid sodium salt; R-HIBA; R-beta-HIBA-Na, Sodium (R)-3-hydroxy-2-methylpropionate |
| Product Type | Chemical |
| Properties | |
| Formula | C4H7O3 . Na |
| MW | 103.1 . 23.0 |
| CAS | 1228078-57-6 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥96% (GC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | RBJZIQZDAZLXEK-AENDTGMFSA-M |
| Smiles | C[C@H](CO)C([O-])=O.[Na+] |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Intermediate formed in the valine catabolism. It is a reactant of the enzymes involved in branched chain amino acid metabolism 3-hydroxyisobutyrate dehydrogenase and 3-hydroxyisobutyryl-CoA hydrolase and it was found to have increased concentrations in MS patient metabolic profiles. This compound may be used to study the distribution, characterization and kinetics of these enzymes. Shown to inhibit key enzymes of the energy metabolism.
Product References
(1) S. Landaas; Clin. Chim. Acta 64, 143 (1975) | (2) F. Podebrad, et al.; Clin. Chim. Acta 292, 93 (2000) | (3) J.W. Hawes, et al.; Methods Enzymol. 324, 218 (2000) | (4) F.J. Loupatty, et al.; Am. J. Hum. Genet. 80, 195 (2007) | (5) C.M. Viegas, et al.; Int. J. Dev. Neurosci. 26, 293 (2008) | (6) R.J. Wanders, et al.; J. Inherit. Metab. Dis. 35, 5 (2012)