Hexamethonium bromide

Specifications / Handling

More Information
Product Details
Synonyms	N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide; Hexane-1,6-bis(trimethylammonium bromide)
Product Type	Chemical
Properties
Formula	C₁₂H₃₀Br₂N₂
MW	362.19
CAS	55-97-0
RTECS	BQ8575000
Source/Host Chemicals	Synthetic
Purity Chemicals	≥98% (TLC)
Appearance	White to off-white powder.
Solubility	Soluble in water (30mg/ml) or DMSO (10mg/ml).
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	FAPSXSAPXXJTOU-UHFFFAOYSA-L
Smiles	C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+20°C
Long Term Storage	+20°C
Handling Advice	Keep under inert gas. Very hygroscopic.
Use/Stability	Stable for at least 2 years after receipt when stored at RT.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Hexamethonium bromide is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs). Formulations containing hexamethonium were previously used in the treatment of hypertension. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation.

Product References

(1) A.R. Hunter; Lancet 1, 251 (1950) | (2) J.A. Gosling & T.C. Lu; J. Pharmacol. Exp. Ther. 167, 56 (1969) | (3) A.C. Villablanca; J. Appl. Physiol. 84, 2089 (1998) | (4) P. Dasgupta, et al.; PNAS 103, 6332 (2010) | (5) Y. Nishida, et al.; J. Physiol. Sci. 62, 147 (2012)

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