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Chemodex
1-Hydroxyibuprofen
103
CHF
CHF 103.00
In stock
CDX-H0943-M01010 mgCHF 103.00
| Product Details | |
|---|---|
| Synonyms | Ibuprofen Impurity L; Ibuprofen EP Impurity L; 2-[4-(1-Hydroxy-2-methylpropyl)phenyl]propanoic acid; 1-OH IBU |
| Product Type | Chemical |
| Properties | |
| Formula | C13H18O3 |
| MW | 222.28 |
| CAS | 53949-53-4 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder or crystals. |
| Solubility | Soluble in DMSO, DMF, ethanol or methanol (all 10mg/ml). Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | RMOQYHYFRKTDRI-UHFFFAOYSA-N |
| Smiles | CC(C)C(O)c1ccc(cc1)C(C)C(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
The metabolite 1-Hydroxyibuprofen (Ibuprofen Impurity L) is a degradation product of Ibuprofen which is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain from various conditions such as headache, dental pain or menstrual cramps. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2. Ibuprofen is metabolized in the human liver to a number of metabolites including 1-hydroxyibuprofen (1-OH-Ibu), 2-OH-Ibu and 3-OH-Ibu, respectively. 1-Hydroxyibuprofen was determined as the dominant compound in soils. This product can be used as a working standard or secondary analytical reference standard.
Product References
(1) I. Neunzig, et al.; J. Biotechnol. 157, 417 (2012) | (2) Z. Han, et al.; Chromatographia 80, 1353 (2017) | (3) E. Waraksa, et al.; J. Pharm. Biomed. Anal. 152, 279 (2018) | (4) T. Dolu & B. Nas; Environ. Res. 227, 115731 (2023)