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Chemodex
Isorhamnetin
95
CHF
CHF 95.00
In stock
CDX-I0174-M0055 mgCHF 95.00
| Product Details | |
|---|---|
| Synonyms | 3'-Methoxy-3,4',5,7-tetrahydroxyflavone; 3'-Methylquercetin; Isorhamnetol; Quercetin 3'-methyl ether; BRN 0044723 |
| Product Type | Chemical |
| Properties | |
| Formula |
C16H12O7 |
| MW | 316.26 |
| CAS | 480-19-3 |
| RTECS | LK9275450 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Beige to light yellow powder. |
| Solubility | Soluble in DMSO (20mg/ml) or DMF (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | IZQSVPBOUDKVDZ-UHFFFAOYSA-N |
| Smiles | O=C1C2=C(O)C=C(O)C=C2OC(C3=CC=C(O)C(OC)=C3)=C1O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin. It shows diverse biological activities, including antioxidant, cardioprotective, anti-inflammatory, neuroprotective, antiobesity, antiviral, antituberculosis and anticancer properties. Isorhamnetin exerts anticancer activity, through induction of apoptosis and inhibition of cell proliferation and invasion. It suppresses colon cancer cell growth through the PI3K-Akt-mTOR pathway. It inhibits the NF-κB signaling pathway. Isorhamnetin selectively inhibited NLRP3 and AIM2 inflammasome activation and down-regulated expression of pro-inflammatory cytokines. It has powerful antioxidant action through its ability to scavenge free radicals and inhibits xanthine oxidase. Isorhamnetin is a PPARγ antagonist and inhibits adipogenesis, with beneficial effect on the prevention and treatment of obesity.
Product References
(1) A. Nagao, et al. Biosci. Biotechnol. Biochem. 63, 1787 (1999) | (2) B.S. Teng, et al.; Pharmacol. Res. 54, 186 (2006) | (3) G. Ma, et al.; Chem. Biol. Interact. 167, 153 (2007) | (4) M. Sanchez, et al.; J. Nutr. 137, 910 (2007) | (5) L. Pengfei, et al.; Plant Foods Hum. Nutr. 64, 141 (2009) | (6) S. Jaramillo, et al.; J. Agric. Food Chem. 58, 10869 (2010) | (7) L. Ramachandran, et al.; J. Biol. Chem. 287, 38028 (2012) | (8) J.H. Yang, et al.; Food Chem. Toxicol. 59, 362 (2013) | (9) C. Li, et al.; Mol. Med. Rep. 9, 935 (2014) | (10) S. Chirumbolo; Inflammation 37, 1200 (2014) | (11) A. Abdal Dayem, et al.; PLoS One 10, e0121610 (2015) | (12) H.N. Jnawali, et al.; J. Nat. Prod. 79, 961 (2016) | (13) Y. Zhang, et al.; Sci. Rep. 6, 19288 (2016) | (14) H. Ahn & G.S. Lee; Phytomedicine 24, 77 (2017) | (15) J. Wei, et al.; Exp. Ther. Med. 15, 3917 (2018)
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