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AdipoGen Life Sciences
Quercetin . dihydrate
35
CHF
CHF 35.00
In stock
AG-CN2-0409-G0011 gCHF 35.00
AG-CN2-0409-G0055 gCHF 90.00
| Product Details | |
|---|---|
| Synonyms | Sophoretin; Meletin; Xanthaurine; Quercetol; Quercitin; Quertine; Flavin meletin; NCI-C60106; NSC9219; NSC9221; CI 75670; CI Natural Yellow 10; BRN0317313 |
| Product Type | Chemical |
| Properties | |
| Formula |
C15H10O7 . 2H20 |
| MW | 302.2 . 36.0 |
| Merck Index | 14: 8034 |
| CAS | 6151-25-3 |
| RTECS | LK8950000 |
| Source/Host Chemicals | Isolated from Umbelliferae sp. |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | Pale yellow powder. |
| Solubility | Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water. |
| Identity | Determined by 1H-NMR. |
| InChi Key | REFJWTPEDVJJIY-UHFFFAOYSA-N |
| Smiles | OC1=CC(O)=C2C(OC(=C(O)C2=O)C2=CC=C(O)C(O)=C2)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Multipotent flavonoid antioxidant.
- Potent free radical scavenger.
- Neuroprotective.
- Anticancer compound with chemosensitizing activity.
- Cell cycle arrest, apoptosis and autophagy inducer.
- Proteasome inhibitor.
- Pleiotropic kinase inhibitor, including tyrosine protein kinase (Trk), mitochondrial ATPase, cAMP- and cGMP-phosphodiesterases, PI3-kinase activity, phospholipase A2 and protein kinase C (PKC).
- DNA topoisomerases inhibitor.
- SIRT1 activator.
- Heat shock proteins inhibitor.
- Reversible fatty acid synthase inhibitor.
- Antithrombotic, antihistaminic and anti-inflammatory agent.
- Monoamine oxidase inhibitor.
- Vasodilatory compound.
- Anti-diabetic compound.
- Antiviral for the prevention and treatment of SARS-CoV-2 related disease (COVID-19)
Product References
- Pharmacological inhibitors of Fatty Acid Synthase (FASN) - catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? R. Lupu & J.A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006) (Review)
- Health effects of quercetin: from antioxidant to nutraceutical: A.W. Boots, et al.; Eur. J. Pharmacol. 585, 325 (2008) (Review)
- Multitargeted cancer prevention by quercetin: A. Murakami, et al.; Cancer Lett. 269, 315 (2008) (Review)
- Inhibiting the transcription factor HSF1 as an anticancer strategy: L. Whitesell & S. Lindquist; Expert Opin. Ther. Targets 13, 469 (2009) (Review)
- In vitro modulation of naturally occurring flavonoids on cytochrome P450 2A6 (CYP2A6) activity: K.H. Tiong, et al.; Xenobiotica 40, 458 (2010) (Review)
- Regulation of SIRT1 in cellular functions: role of polyphenols: S. Chung, et al.; Arch. Biochem. Biophys. 501, 79 (2010) (Review)
- Quercetin as a systemic chemopreventative agent: structural and functional mechanisms: E.E. Mendoza & R. Burd; Mini Rev. Med. Chem. 11, 1216 (2011) (Review)
- Exploiting tyrosinase expression and activity in melanocytic tumors: quercetin and the central role of p53: A.J. Vargas, et al.; Integr. Cancer Ther. 10, 328 (2011) (Review)
- Targeting tumor ubiquitin-proteasome pathway with polyphenols for chemosensitization: M. Shen, et al.; Anticancer Agents Med. Chem. 12, 891 (2012) (Review)
- Flavonoids acting on DNA topoisomerases: recent advances and future perspectives in cancer therapy: P. Russo, et al.; Curr. Med. Chem. 19, 5287 (2012) (Review)
- Life or death: neuroprotective and anticancer effects of quercetin: F. Dajas; J. Ethnopharmacol. 143, 383 (2012) (Review)
- Phytochemicals and their impact on adipose tissue inflammation and diabetes: A. Leiherer, et al.; Vascul. Pharmacol. 58, 3 (2013) (Review)
- Autophagy, polyphenols and healthy ageing: K. Pallauf & G. Rimbach; Ageing Res. Rev. 12, 237 (2013) (Review)
- Quercetin: a pleiotropic kinase inhibitor against cancer: G.L. Russo; Cancer Treat. Res. 159, 185 (2014) (Review)
- Quercetin can reduce insulin resistance without decreasing adipose tissue and skeletal muscle fat accumulation: N. Arias, et al.; Genes Nutr. 9, 361 (2014)
- Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19): R.M.L. Colunga Biancatelli, et al.; Front. Immunol. 11, 1451 (2020)(Review)
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