CHF 164.00
In stock
CDX-M0004-M100100 mgCHF 164.00
CDX-M0004-M500500 mgCHF 544.00
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Product Details
Synonyms 2-Methoxy-5-(N-phthalimidinyl)benzenesulfonyl chloride
Product Type Chemical
Formula C15H12ClNO4S
MW 337.78
CAS 126565-42-2
Source/Host Chemicals Synthetic.
Purity Chemicals ≥97% (Elemental Analysis)
Appearance Solid.
Solubility Soluble in DMSO.
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Smiles COC1=CC=C(C=C1S(Cl)(=O)=O)N1CC2=CC=CC=C2C1=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

It is known that phenol and p-cresol are promoters of skin tumors and also urinary excretion of phenol and p-cresol is increased by exposure to benzene, which has hemopoietic toxicity, and toluene, respectively. Therefore, the determination of phenol and p-cresol is important in clinical chemistry and toxicology. Because phenol and p-cresol are present in urine as sulfate or glucuronide conjugates, they are hydrolyzed enzymatically or with acid, followed by distillation or extraction with organic solvent prior to measurement by GC or HPLC. However, these GC and HPLC methods require relatively large sample volumes (more than 1 ml) because of their insufficient sensitivities for measuring small amounts of phenol and p-cresol. In the general, the application of fluorescent labeling techniques to HPLC result in a sensitive and selective method. Some acyl chlorides are known to react with phenolic hydroxy group to form esters. It is known that 4-(N-phthalimidinyl)benzensulfonyl chloride Phisyl-Cl7, having sulfonyl chloride, reacted with phenol to give the corresponding highly fluorescent sulfonyl ester. The sensitivity of Physil-Cl was compared with Dansyl-Cl and DPS-Cl, which are analogous to Physil-Cl as fluorescent labeling reagents having sulfonyl chloride group. The labeling reaction of phenol with Dansyl-Cl and DPS-Cl were carried out according to the method of Ruiter et al.5 and the peaks were detected at the each fluorescence maxima wavelength (Ex350nm a Em550nm for Dansyl-Cl, and Ex320nm a Em386nm for DPS-Cl). Peak height of Phisyl derivative was higher about 85-and 7,3-fold than thosse of Dansyl derivative and DPS derivative, respectively. Among these three reagents, Phisyl-Cl was the most sensitive.

Product References

(1) Y. Tsuruta et al.; J. Chromatogr. 8, 178 (1994) | (2) K. Imai et al.; Biomed. Chromatogr. 8, 107 (1994) | (3) C. Ruiter et al.; Anal. Chem 60, 666 (1988) | (4) R.M. Cassidy et al.; J. Chromatogr. Sci. 12, 85 (1974)

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