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Chemodex
TSQ
As low as
271
CHF
CHF 271.00
In stock
Only %1 left
CDX-M0065-M100100 mgCHF 271.00
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| Product Details | |
|---|---|
| Synonyms | N-(6-Methoxy-8-quinolyl)-p-toluenesulfonamide; N-(6-Methoxy-8-quinolinyl)-4-methylbenzenesulfonamide; NSC 120213 |
| Product Type | Chemical |
| Properties | |
| Formula | C17H16N2O3S |
| MW | 328.39 |
| CAS | 109628-27-5 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to yellow to beige powder. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | HKRNYOZJJMFDBV-UHFFFAOYSA-N |
| Smiles | O=S(NC1=CC(OC)=CC2=CC=CN=C21)(C3=CC=C(C)C=C3)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
TSQ (N-(6-Methoxy-8-quinolyl)-p-toluenesulfonamide) is a highly sensitive, membrane-permeable fluorescent probe widely used for the selective detection and imaging of intracellular zinc (Zn2+) ions. It is selective for Zn (II) in the presence of physiological concentrations of Ca (II) and Mg (II) ions. Upon binding to Zn2+, TSQ exhibits a strong blue fluorescence, making it a powerful tool in cellular and neurobiological studies involving zinc homeostasis, signaling, and transport. It is hypothesized that Zn-TSQ fluorescence, blue-shifted from the 490 nm emission maximum of Zn(TSQ)2, results from ternary complex, TSQ-Zn-protein formation. A study showed that TSQ-zinc complex formed in pancreatic tumors induced cell death if zinc is overloaded. TSQ is commonly applied in fluorescence microscopy and flow cytometry to visualize labile zinc pools in live cells and tissues. Spectral Data: λEx=360nm; λEm=490nm.
Product References
(1) C.J. Frederickson, et al.; J. Neurosci. Meth. 20, 91 (1987) | (2) D.D. Savage, et al.; Brain Res. 496, 257 (1989) | (3) J.C. Andrews, et al.; Cytometry 21, 153 (1995) | (4) J.W. Meeusen, et al.; Inorg. Chem. 50, 7563 (2011) | (5) M.R. Karim, et al.; Metallomics, Int. Biometal Sci. 9, 391 (2016) | (6) T.M. Horton, et al.; Cell Chem. Biol. 26, 213 (2018) | (7) K. Asahina; Biol. Trace Elem. Res. 200, 1667 (2022)