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Chemodex
Tetra-O-methylscutellarein
162
CHF
CHF 162.00
In stock
CDX-M0514-M0011 mgCHF 162.00
CDX-M0514-M0055 mgCHF 489.00
| Product Details | |
|---|---|
| Synonyms | Scutellarein tetramethyl ether; 5-Methoxysalvigenin; 4',5,6,7-Tetramethoxyflavone; NSC53908 |
| Product Type | Chemical |
| Properties | |
| Formula |
C19H18O6 |
| MW | 342.3 |
| CAS | 1168-42-9 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to yellow powder. |
| Solubility | Soluble in DMSO (20mg/ml) or chloroform. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | URSUMOWUGDXZHU-UHFFFAOYSA-N |
| Smiles | O=C(C=C(C1=CC=C(OC)C=C1)O2)C3=C2C=C(OC)C(OC)=C3OC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Tetra-O-methylscutellarein is a bioactive component of Siam weed extract. It exhibits anti-inflammatory activity through inhibition of the NF-κB pathway. It suppressed IκB kinase complex alpha/beta (IKKα/β) and Inhibitory-kappa-B-alpha (IκBα), inhibiting p65 translocation and thereby suppressing COX-2 and iNOS expression. This compound is modulating bacterial resistance to antimicrobial drugs most probably via efflux pump inhibition. It also showed anti-mutagenic activity.
Product References
(1) M. Miyazawa, et al.; J. Agric. Food Chem. 47, 5239 (1999) | (2) G.L. Maia, et al.; Molecules 16, 4828 (2011) | (3) H. Pandith, et al.; J. Ethnopharmacol. 147, 434 (2013)