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Chemodex
Medetomidine HCl
95
CHF
CHF 95.00
In stock
CDX-M0559-M01010 mgCHF 95.00
CDX-M0559-M05050 mgCHF 380.00
| Product Details | |
|---|---|
| Synonyms | 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride; Domitor; MPV 785; Metomidine; Zalopine; Detomidine HCl |
| Product Type | Chemical |
| Properties | |
| Formula | C13H17ClN2 |
| MW | 236.75 |
| CAS | 86347-15-1 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water (20mg/ml) or DMSO (20mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | VPNGEIHDPSLNMU-UHFFFAOYSA-N |
| Smiles | CC1=CC=CC(C(C)C2=CNC=N2)=C1C.Cl |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Medetomidine is an imidazole derivative. It acts as a potent selective agonist of α2-adrenoceptors (Ki=1.08nM vs. 1750nM for α1-adrenoceptors). Through its effect on α2-adrenoceptors, medetomidine has sedative, antinociceptive, hypotenisve, bradycardic, anxiolytic, analgesic and hypothermic actions. Its effects on pain are additive or synergistic with fentanyl-type opioids. The effects of medetomidine are effectively countered by α2-adrenoceptor antagonists, like atipamezole. Selective α2-adrenoceptor agonists, including medetomidine, have anesthetic sparing properties, greatly reducing the dose of anesthetic required following premedication with the α2-adrenoceptor agonist.
Product References
(1) J.M. Savola, et al.; J. Auton. Pharmacol. 6, 275 (1986) | (2) R. Virtanen, et al.; Eur. J. Pharmacol. 150, 9 (1988) | (3) M.H. Ossipov, et al.; Anesthesiology 73, 1227 (1990) | (4) T.F. Meert, & M. de Kock; Anesthesiology 81, 677 (1994) | (5) J.C. Hunter, et al.; Br. J. Pharmacol. 122, 1339 (1997) | (6) H. Scheinin, et al.; Anesthesiology 89, 574 (1998) | (7) M.D. Sinclair; Can. Vet. J. 44, 885 (2003)