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Chemodex
Nigericin sodium salt
77
CHF
CHF 77.00
In stock
CDX-N0094-M0055 mgCHF 77.00
CDX-N0094-M01010 mgCHF 135.00
CDX-N0094-M05050 mgCHF 490.00
| Product Details | |
|---|---|
| Synonyms | Antibiotic X464; Azalomycin M; Polyetherin A; Antibiotic K178; Helexin C |
| Product Type | Chemical |
| Properties | |
| Formula | C40H67NaO11 |
| MW | 746.94 |
| CAS | 28643-80-3 |
| RTECS | QT6840000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (TLC) |
| Appearance | White to yellow powder. |
| Solubility | Soluble in methanol or ethanol. Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | MOYOTUKECQMGHE-PDEFJWSRSA-M |
| Smiles | [Na+].[H][C@@]1(CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@]2([H])C[C@@H](OC)[C@@H](C)[C@]3(O2)O[C@@](C)(C[C@H]3C)[C@@]4([H])CC[C@](C)(O4)[C@]5([H])O[C@]([H])(C[C@@H]5C)[C@@]6([H])O[C@@](O)(CO)[C@H](C)C[C@@H]6C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Nigericin is an antibiotic, used as a high affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+. It shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity and disrupts membrane potential of mitochondria. It sprimary use is as a NLRP3 activator in inflammasome research.
Product References
(1) R. L. Harned, et al.; Antibiot. Chemother. 1, 594 (1951) | (2) S. Estrada-O, et al.; J. Biol. Chem. 242, 2925 (1967) | (3) D. Perregaux, et al.; J. Immunol. 149, 1294 (1992) | (4) B. Baibakov, et al.; Int. J. Oncol. 3, 1127 (1993) | (5) N. Watanabe, et al.; Cytokine 10, 645 (1998) | (6) S. Mariathasan, et al.; Nature 440, 228 (2006) | (7) C. Wang, et al.; Sci. Immunol. 6, eabj3859 (2021)