Naphthol AS-E phosphate

Specifications / Handling

More Information
Product Details
Synonyms	N-(4-Chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide; KG-501; NASEP
Product Type	Chemical
Properties
Formula	C₁₇H₁₃ClNO₅P
MW	377.72
CAS	18228-17-6
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥99% (HPLC)
Appearance	Beige powder.
Identity	Determined by NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	RQAQWBFHPMSXKR-UHFFFAOYSA-N
Smiles	OP(O)(=O)OC1=CC2=CC=CC=C2C=C1C(=O)NC1=CC=C(Cl)C=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Histochemical substrate for alkaline phosphatases. Aldolase inhibitor. Small molecule inhibitor. Anticancer compound that directly targets the KIX domain of CBP, resulting in a disrupted CREB-CBP complex, inhibited CREB-target gene induction and inhibited IL-1β-mediated angiogenic activity in cancer cell lines. Inhibits activity of transcription factor Myb by blocking interaction with KIX domain of coactivator p300 in human leukemia cells. Interferes with the Myb–KIX interaction in vitro and inhibits Myb activity in vivo. Suppresses the expression of Myb target genes and induces myeloid differentiation and apoptosis.

Product References

(1) Z. Lojda, et al.; Histochemie 11, 13 (1967) | (2) J.L. Best, et al.; PNAS 101, 17622 (2004) | (3) M. St-Jean, et al.; J. Biol. Chem. 282, 14309 (2007) | (4) B.X. Li & X. Xiao, et al.; ChemBioChem 10, 2721 (2009) | (5) J.W. Lee, et al.; PLoS One 10, e0122628 (2015) | (6) S. Uttarkar, et al.; Mol. Cancer Ther. 14, 1276 (2015)

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