Naphthol AS-E phosphate

CHF 115.00
In stock
CDX-N0125-M500500 mgCHF 115.00
CDX-N0125-G0011 gCHF 198.00
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Product Details
Synonyms N-(4-Chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide; KG-501; NASEP
Product Type Chemical
Properties
Formula C17H13ClNO5P
MW 377.72
CAS 18228-17-6
Source/Host Chemicals Synthetic.
Purity Chemicals ≥99% (HPLC)
Appearance Beige powder.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key RQAQWBFHPMSXKR-UHFFFAOYSA-N
Smiles OP(O)(=O)OC1=CC2=CC=CC=C2C=C1C(=O)NC1=CC=C(Cl)C=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Histochemical substrate for alkaline phosphatases. Aldolase inhibitor. Small molecule inhibitor. Anticancer compound that directly targets the KIX domain of CBP, resulting in a disrupted CREB-CBP complex, inhibited CREB-target gene induction and inhibited IL-1β-mediated angiogenic activity in cancer cell lines. Inhibits activity of transcription factor Myb by blocking interaction with KIX domain of coactivator p300 in human leukemia cells. Interferes with the Myb–KIX interaction in vitro and inhibits Myb activity in vivo. Suppresses the expression of Myb target genes and induces myeloid differentiation and apoptosis.

Product References

(1) Z. Lojda, et al.; Histochemie 11, 13 (1967) | (2) J.L. Best, et al.; PNAS 101, 17622 (2004) | (3) M. St-Jean, et al.; J. Biol. Chem. 282, 14309 (2007) | (4) B.X. Li & X. Xiao, et al.; ChemBioChem 10, 2721 (2009) | (5) J.W. Lee, et al.; PLoS One 10, e0122628 (2015) | (6) S. Uttarkar, et al.; Mol. Cancer Ther. 14, 1276 (2015)

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