Chemodex

Naphthol AS-TR phosphate

CHF 193.00
In stock
CDX-N0128-G0011 gCHF 193.00
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Product Details
Synonyms N-(4-chloro-2-methylphenyl)-3-(phosphonooxy)-2-Naphthalenecarboxamide; NASTRp
Product Type Chemical
Properties
Formula C18H15CINO5P
MW 391.74
CAS 2616-72-0
Source/Host Chemicals Synthetic
Purity Chemicals ≥99% (HPLC)
Appearance White to off-white powder.
Solubility Soluble in DMF or TRIS-HCl buffer.
Identity Determined by 1H-NMR.
Declaration Manufactured by Chemodex.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key SHTFMUPUBYXPCD-UHFFFAOYSA-N
Smiles O=C(NC1=C(C)C=C(Cl)C=C1)C2=CC3=CC=CC=C3C=C2OP(O)(O)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep under inert gas.
Very hygroscopic.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF
Description

Naphthol AS-TR Phosphate is a fluorogenic substrate for acid and alkaline phosphatases. Naphthol AS-TR Phosphate is converted to naphthol AS-TR displaying excitation/emission spectra of 388/512nm. The fluorescence is a quantitative marker of acid and alkaline phosphatase activity. Acid and alkaline phosphatases are often used as clinical markers of disease, since the concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. It is a histochemical substrate commonly used in conjunction with diazonium salts to form a specific azo dye for immunohistology applications. Naphthol AS-TR Phosphate is a cyclic-AMP response element-binding protein (CREB)-CREB binding protein (CBP) transcription factor complex inhibitor and a potential therapeutic agent for lung cancer.

Product References

(1) Z. Lojda, etal.; Histochemie 11, 13 (1967) | (2) G.G. Guilbault & A. Vaughan; Anal. Lett. 3, 1 (1970) | (3) A. Vaughan, et al.; Anal. Chem. 43, 721 (1971) | (4) A.S.H.De Jong, et al.; Histochem. J. 17, 1119 (1985) | (5) R. Hong, et al.; Anal. Chem. 86, 1459 (2014) | (6) J.W. Lee, et al.; PLoS One 10, e0122628 (2015)

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