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Chemodex
Naphthol AS-TR phosphate
193
CHF
CHF 193.00
In stock
CDX-N0128-G0011 gCHF 193.00
| Product Details | |
|---|---|
| Synonyms | N-(4-chloro-2-methylphenyl)-3-(phosphonooxy)-2-Naphthalenecarboxamide; NASTRp |
| Product Type | Chemical |
| Properties | |
| Formula | C18H15CINO5P |
| MW | 391.74 |
| CAS | 2616-72-0 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMF or TRIS-HCl buffer. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | SHTFMUPUBYXPCD-UHFFFAOYSA-N |
| Smiles | O=C(NC1=C(C)C=C(Cl)C=C1)C2=CC3=CC=CC=C3C=C2OP(O)(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Very hygroscopic. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Naphthol AS-TR Phosphate is a fluorogenic substrate for acid and alkaline phosphatases. Naphthol AS-TR Phosphate is converted to naphthol AS-TR displaying excitation/emission spectra of 388/512nm. The fluorescence is a quantitative marker of acid and alkaline phosphatase activity. Acid and alkaline phosphatases are often used as clinical markers of disease, since the concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. It is a histochemical substrate commonly used in conjunction with diazonium salts to form a specific azo dye for immunohistology applications. Naphthol AS-TR Phosphate is a cyclic-AMP response element-binding protein (CREB)-CREB binding protein (CBP) transcription factor complex inhibitor and a potential therapeutic agent for lung cancer.
Product References
(1) Z. Lojda, etal.; Histochemie 11, 13 (1967) | (2) G.G. Guilbault & A. Vaughan; Anal. Lett. 3, 1 (1970) | (3) A. Vaughan, et al.; Anal. Chem. 43, 721 (1971) | (4) A.S.H.De Jong, et al.; Histochem. J. 17, 1119 (1985) | (5) R. Hong, et al.; Anal. Chem. 86, 1459 (2014) | (6) J.W. Lee, et al.; PLoS One 10, e0122628 (2015)