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Chemodex
Nadolol
61
CHF
CHF 61.00
In stock
CDX-N0141-G0011 gCHF 61.00
CDX-N0141-G0055 gCHF 244.00
| Product Details | |
|---|---|
| Synonyms | Corgard; SQ11725 |
| Product Type | Chemical |
| Properties | |
| Formula |
C17H27NO4 |
| MW | 309.4 |
| CAS | 42200-33-9 |
| RTECS | QJ4870000 |
| Purity Chemicals | ≥98% (GC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (20mg/ml) or DMF. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | VWPOSFSPZNDTMJ-UCWKZMIHSA-N |
| Smiles | O[C@H]1[C@@H](O)CC2=C(OCC(O)CNC(C)(C)C)C=CC=C2C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Nadolol is a polar and hydrophilic, non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. It is a long-acting beta-blocker, which displays activity against beta-1 and beta-2 receptors. It has a preference for beta-1 receptors, which are predominantly located in the heart, thereby inhibiting the effects of catecholamines and causing a decrease in heart rate and blood pressure. Nadolol's inhibition of beta-1 receptors in the heart and kidney leads to its effects on lowering blood pressure. Its inhibition of beta-2 receptors, which are mainly located in the bronchial smooth muscle of the airways, leads to airway constriction similar to that seen in asthma.
Product References
(1) D.B. Evans, et al.; Eur. J. Pharmacol. 35, 17 (1976) | (2) W. Frishman; Am. Heart J. 99, 124 (1980) (Review) | (3) R.C. Heel, et al.; Drugs 20, 1 (1980) (Review) | (4) W.H. Frishman; N. Engl. J. Med. 305, 678 (1981) (Review) | (5) H. Peng, et al.; 383, 209 (2011)