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Chemodex
4-Nitrophenyl butyrate
As low as
161
CHF
CHF 161.00
In stock
Only %1 left
CDX-N0185-G0055 gCHF 161.00
CDX-N0185-G01010 gCHF 277.00
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Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | 4-NPB; p-Nitrophenyl butyrate; 4-Nitrophenyl ester butyric acid; p-Nitrophenol butyrate; p-NPB; NSC6867 |
| Product Type | Chemical |
| Properties | |
| Formula | C10H11NO4 |
| MW | 209.2 |
| CAS | 2635-84-9 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (TLC) |
| Appearance | Green-yellow to yellow liquid. |
| Solubility | Soluble in chloroform, DMSO, DMF or ethanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | DVDUMIQZEUTAGK-UHFFFAOYSA-N |
| Smiles | O=C(OC1=CC=C(C=C1)N(=O)=O)CCC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
4-Nitrophenyl butyrate is a chromogenic substrate widely used in enzymology and biochemical research for the detection and characterization of esterase and lipase activity. Upon enzymatic hydrolysis, it releases the chromophore 4-nitrophenol, which can be converted to p-nitrophenoxide under alkaline conditions and quantified spectrophotometrically by monitoring its strong absorbance at approximately 405 nm. Due to its high sensitivity and convenient colorimetric readout, 4-nitrophenyl butyrate is commonly used in enzyme kinetics, inhibitor screening and studies of hydrolase activity. It is also used as an intermediate in organic synthesis and chemical research.
Product-specific References
(1) S.H. Sterri, et al.; Biochem. Pharmacol. 34, 2779 (1985) | (2) T. Tsujita, et al.; J. Lipid Res. 30, 997 (1989) | (3) E.T. Williams, et al.; J. Pharmacol. Toxicol. Methods 57, 138 (2008) | (4) P.K. Singh, et al.; Biosci. Rep. 36, e00331 (2016) | (5) M.S. Rodrigues, et al.; Eur. J. Neurosci. 55, 1051 (2022) | (6) Q. Song, et al.; Polym. Chem. 14, 4712 (2023)