Chemodex
β-Nicotinamide adenine dinucleotide hydrate
| Product Details | |
|---|---|
| Synonyms | β-DPN; β-NAD; Coenzyme 1; Cozymase; DPN; Diphosphopyridine nucleotide; NAD; Nadide; NSC 20272 |
| Product Type | Chemical |
| Properties | |
| Formula | C21H27N7O14P2 . xH2O |
| MW | 663.43 (anhydrous basis) |
| CAS | 53-84-9 |
| RTECS | UU3450000 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to yellow powder. |
| Solubility | Soluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | BAWFJGJZGIEFAR-OMYDKTABSA-N |
| Smiles | O[C@H]1C(N2C=NC3=C2N=CN=C3N)O[C@H](COP(O)(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@@H]([N+]5=CC(C(N)=O)=CC=C5)O4)([O-])=O)=O)[C@H]1O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
NAD+, known more formally as nicotinamide adenine dinucleotide, is a signaling molecule as well as a cofactor or substrate for many enzymes. It acts as an oxidizing agent, accepting electrons from other molecules while being converted to its reduced form, NADH. NAD+ is also essential for the activity of several enzymes, including poly(ADP)-ribose polymerases and cADP-ribose synthases. For example, it is used by some sirtuins to mediate protein deacetylation, producing O-acetyl-ADP-ribose and nicotinamide as well as the deacetylated protein. NAD+ is an important player and factor to research metabolic pathways and pathologies.
(1) B. Schwer & E. Verdin; Cell Metabolism 7, 104 (2008) (Review) | (2) R.H. Houtkooper, et al.; Endocr. Rev. 31, 194 (2010) (Review) | (3) Y.S. Elhassan, et al.; J. Endocr. Soc. 1, 816 (2017) (Review)