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Chemodex
Nequinate
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| Product Details | |
|---|---|
| Synonyms | Methyl benzoquate; Neqoinate; Mequinate; AY 20385; ICI 55052; Methyl 7-(benzyloxy)-6-n-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate |
| Product Type | Chemical |
| Properties | |
| Formula | C22H23NO4 |
| MW | 365.42 |
| CAS | 13997-19-8 |
| Source/Host Chemicals | Synthetic |
| Appearance | White to light yellow to brown powder. |
| Solubility | Soluble in DMSO (10mg/ml) or ethanol (1mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | NNOPDLNHPOLRRE-UHFFFAOYSA-N |
| Smiles | O=C1C2=CC(CCCC)=C(OCC3=CC=CC=C3)C=C2NC=C1C(OC)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Nequinate is a quinoline anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections. It is studied for its efficacy against protozoan parasites of the genus Eimeria. The mode of action involves the inhibition of mitochondrial electron transport in the parasites, such as inhibiting xanthine oxidoreductase (XOD) activity, thus disrupting the energy metabolism. Anticoccidial drugs are a class of compounds used to prevent or treat coccidiosis, an intestinal disease caused by protozoan parasites of the genus Eimeria (and occasionally Isospora) in animals, particularly poultry and livestock. Nequinate serves as a reference compound in pharmacological and biochemical studies exploring quinoline-based inhibitors of protozoan metabolism. Compound can be used as analytical reference material.
Product References
(1) D.K. McLoughlin & M.B. Chute; Avian Dis. 17, 717 (1973) | (2) G.H. Merson, et al.; Analyst 110, 761 (1985) | (3) R.B. Williams; Int. J. Parasitol. 27, 101 (1997) | (4) Y. Niu, et al.; J. Pharmacol. Sci. 135, 114 (2017) | (5) S. Noack, et al.; Parasitol. Res. 118, 2009 (2019)