|Synonyms||3-oxo-C14-HSL; 3OC14-HSL; N-3-oxo-Myristoyl-L-Homoserine lactone|
|Purity Chemicals||≥97% (GC)|
|Solubility||Soluble in chloroform.|
|Identity||Determined by NMR.|
|Declaration||Manufactured by Chemodex.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Keep cool and dry.
Protect from light and moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
N-(3-Oxotetradecanoyl)-L-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms. It appears later than shorter acyl chain AHLs in developing biofilms and like other long chain 3-oxo-AHLs, stimulates the production of putisolvin, which in turn inhibits biofilm formation.
(1) A. Kuo, et al.; J. Bacteriol. 176, 7558 (1994) | (2) A.L. Schaefer, et al.; J. Bacteriol. 178, 2897 (1996) | (3) K.H. McClean, et. al.; Microbiol. 143, 3703 (1997) | (4) J.K. Lithgow, et al.; Mol. Microbiol. 37, 81 (2000) | (5) S.R. Chhabra, et al.; J. Med. Chem. 46, 97 (2003) | (6) G.D. Geske; JACS 127, 12762 (2005) | (7) J.F. Dubern, et al.; J. Bacteriol. 188, 2898 (2006) | (8) F.W. Bartels, et al.; Biophys. J. 92, 4391 (2007) | (9) A.M. Pomini & A.J. Marsaioli; J. Nat. Prod. 71, 1032 (2008) | (10) M. Wahjudi, et al.; Microbiol 157, 2042 (2011) | (11) B.M. Davis, et al.; Biophy. J. 101, 245 (2011) | (12) C.H. Tan, et al.; ISME J. 8, 1186 (2014) | (13) K.-G. Chan, et al.; Sci. World J. 2014, ID891041 (2014)