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Chemodex
Oxymatrine
81
CHF
CHF 81.00
In stock
CDX-O0077-M100100 mgCHF 81.00
CDX-O0077-M500500 mgCHF 170.00
| Product Details | |
|---|---|
| Synonyms | Matrine 1-oxide; Matrine N-oxide; Ammothamnine |
| Product Type | Chemical |
| Properties | |
| Formula | C15H24N2O2 |
| MW | 264.36 |
| CAS | 16837-52-8 |
| RTECS | OQ1770000 |
| Source/Host Chemicals | Isolated from plant source. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in ethanol (25mg/ml), methanol, DMSO, DMF or water (all 10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | XVPBINOPNYFXID-LHDUFFHYSA-N |
| Smiles | [O-][N+]12CCC[C@]3([H])[C@@]1([H])[C@]([C@](CCCC4=O)([H])N4C3)([H])CCC2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Oxymatrine is a natural alkaloid from plants used in traditional Chinese herbal medicine. It has antiviral properties, inhibiting the replication of hepatitis B (HBV) through heat-stress cognate 70 (Hsc70) downregulation. Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-β signaling. This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of NF-κB. Neuroprotective by inhibition of apoptosis in neurons.
Product References
(1) X.L. Wu, et al.; World J. Gastroenterol. 14, 2100 (2008) | (2) J.W. Ngan, et al.; Anticancer Agents Med. Chem. 9, 823 (2009) (Review) | (3) X. Cui, et al.; Biosci. Trends 4, 39 (2010) | (4) X.Q. Dong, et al.; Inflamm. Res. 60, 533 (2010) | (5) Q. Ling, et al.; J. Exp. Clin. Cancer Res. 30, 66 (2011) | (6) X.C. Shen, et al.; J. Asian Nat. Prod. Res. 13, 215 (2011) | (7) N.L. Chai, et al.; World J. Gastroenterol. 18, 4199 (2012) | (8) J.R. Guzman, et al.; Sci. Rep. 3, 1629 (2013) | (9) C.E. Halim, et al.; Pharmacol. Res. 147, 104327 (2019) (Review)