Ononin

Specifications / Handling

More Information
Product Details
Synonyms	Formononetin 7-O-β-D-glucopyranoside; Ononoside
Product Type	Chemical
Properties
Formula	C₂₂H₂₂O₉
MW	430.4
CAS	486-62-4
Source/Host Chemicals	Plant
Purity Chemicals	≥98% (HPLC)
Appearance	White powder.
Solubility	Soluble in DMSO (10mg/ml).
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	MGJLSBDCWOSMHL-MIUGBVLSSA-N
Smiles	O[C@H]1[C@H](OC2=CC=C(C(C(C3=CC=C(OC)C=C3)=CO4)=O)C4=C2)O[C@H](CO)[C@@H](O)[C@@H]1O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+20°C
Long Term Storage	+20°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at RT.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Ononin is a glycoside isoflavone that has been found in soybeans. It has anti-inflammatory activity by inhibiting the NF-κB and MAPK pathways and neuroprotective properties. Ononin inhibits LPS-induced production of nitrite, prostaglandin E2 and the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α by RAW 264.7 macrophages. It also inhibits glutamate-induced toxicity in rat adrenal PC12 cells.

Product References

(1) D. Yu, et al.; J. Ethnopharmacol. 98, 89 (2005) | (2) L. Dong, et al.; Mol. Immunol. 83, 46 (2017) | (3) T. Wang, et al.; J. Sci. Food Agric. 98, 2043 (2018) | (4) Y. Yu, et al.; Pharmacol. Res. 145, 104248 (2019) | (5) L. Luo, et al.; Metabolomics 15, 153 (2019)

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