Ozagrel

Specifications / Handling

More Information
Product Details
Synonyms	OKY-046; (E)-3-(4-((1H-Imidazol-1-yl)methyl)phenyl)acrylic acid
Product Type	Chemical
Properties
Formula	C₁₃H₁₂N₂O₂
MW	228.2
CAS	82571-53-7
RTECS	UD3380000
Source/Host Chemicals	Synthetic
Purity Chemicals	≥98%
Appearance	White to off-white crystalline powder.
Solubility	Soluble in DMSO (5mg/ml) or DMF (5mg/ml). Sligthly solube in ethanol (1mg/ml). Insoluble in water.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	SHZKQBHERIJWAO-AATRIKPKSA-N
Smiles	O=C(/C=C/C1=CC=C(CN2C=NC=C2)C=C1)O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+20°C
Long Term Storage	+20°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at RT.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Ozagrel, an antithrombic drug, is a potent and selective TXA Synthase (thromboxane A2 ; TXAS) inhibitor. Acts as a selective inhibitor of TXAS with an IC50=11nM. The beneficial effects of TXAS inhibition by ozagrel include improved motor coordination after experimental stroke, and antihypertensive effects in spontaneously hypertensive rats.

Product References

(1) J.B. Press, et al.; J. Med. Chem. 29, 816 (1986) | (2) K. Morita, et al.; J. Pharmacobiodyn. 11, 519 (1988)| (3) K. Kawakatsu, et al.; Int. J. Clin. Pharmacol. Ther. Toxicol. 28, 158 (1990)| (4) K. Ichikawa, et al.; Pharmacol. 59, 257 (1999) | (5) O. Moussa, et al.; Oncogene. 27, 55 (2008) | (6) Y. Ishitsuka, et al.; J. Pharmacol. Sci. 111, 211 (2009)

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