Chemodex

Propiconazole

Name: Propiconazole
Brand: Chemodex
SKU: CDX-P0413
Price: 90.00 CHF
Availability: InStock

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CDX-P0413-M250250 mgCHF 90.00

Specifications / Handling

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Product Details
Synonyms	PPZ; CGA 64250; CGD 92710F; Proconazole; Microban S 2140
Product Type	Chemical
Properties
Formula	C₁₅H₁₇Cl₂N₃O₂
MW	342.22
CAS	60207-90-1
RTECS	XZ4620000
Source/Host Chemicals	Synthetic
Purity Chemicals	≥95% (NMR)
Appearance	Yellow to light brown semi-solid.
Solubility	Soluble in DMSO (20mg/ml), DMF, ethanol or acentonitrile.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	STJLVHWMYQXCPB-UHFFFAOYSA-N
Smiles	ClC1=CC(Cl)=CC=C1C2(CN3N=CN=C3)OC(CCC)CO2
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+20°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Propiconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via the demethylation of C-14, leading to fungal cell membrane disruption. Formulations containing propiconazole have been used in the control of fungi in agriculture. It inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450. Propiconazole inhibits the growth of T. deformans and R. stolonifer, as well as A. niger, M. fructigena, S. nodorum, T. harzanium, R. solani, and S. rolfsii at concentrations ranging from 0.1 to 5 ppm. This compound can be used as analytical reference material. Propiconazole increases production of reactive oxygen species (ROS), the number of DNA mutations, and the incidence of tumor formation in mouse liver. Shown to activate PXR and disrupt hepatic metabolism in mice.

Product-specific References

(1) H. Vanden Bossche, te al.; Pestic. Sci. 15, 188 (1984) | (2) M. Sancholle, et al.; Pest. Biochem. Phys. 21, 31 (1984) | (3) J.A. Zarn, et al.; Environ. Health Perspect. 111, 255 (2003) | (4) M. Calonne, et al.; Chemosphere 87, 376 (2012) | (5) C.S. Mazur, et al., Toxicol. Lett. 232, 37 (2015) | (6) N.O. Costa, et al.; Toxicology 335, 55 (2015) | (7) J. Valades, et al.; Environ. Sci. Pollut. Res. Int. 26, 27808 (2019) | (8) B. Attema, et al; Arch. Toxicol. (Epub ahead of print) (2024)

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