|Synonyms||Revolution; Stronghold; (5Z)-25-Cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-alp.-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)avermectin A1a|
|Purity Chemicals||≥99% (HPLC)|
|Solubility||Soluble in DMSO, dichloromethane, ethanol or methanol. Slightly soluble in water.|
|Identity||Determined by 1H-NMR.|
|Declaration||Manufactured by Chemodex.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Shipping and Handling|
|Short Term Storage||+20°C|
|Long Term Storage||+4°C|
Keep cool and dry.
Protect from light and moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at +4°C.|
|Product Specification Sheet|
Avermectin derivative prepared by hydrolysis and oximation of doramectin. Selamectin is a potent nematocide used for the treatment of parasites that acts as agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. In both cases it blocks the transmission of neuronal signals of the parasites, which are either paralyzed and expelled out of the body, or they starve. It also affects the reproduction of some parasites by diminishing oviposition or inducing an abnormal oogenesis. The substance fights both internal and surface parasitic infection. Compound can be used as analytical reference material.
Antiviral effective against 2019-nCoV
(1) B.F. Bishop, et al.; Vet. Parasitol. 91, 163 (2000) | (2) R.H. Six, et al.; Vet. Parasitol. 91, 321 (2000) | (3) B.J. Banks, et al.; Bioorg. Med. Chem. 8, 2017 (2000) | (4) J. Griffin, et al.; J. Vet. Pharmacol. Ther. 28, 257 (2005) | (5) M.U. Esatgil, et al.; Pol. J. Vet. Sci. 11, 67 (2008) | (6) M.U. Esatgil, et al.; Pol. J. Vet. Sci. 11, 143 (2008) | (7) J. Geyer, et al.; J. Vet. Pharmacol. Ther. 32, 87 (2009) | (8) A. Melotti, et al.; EMBO Mol. Med. 6, 1263 (2014)
Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus-related coronavirus model: H.H. Fan, et al.; Chin. Med. J. 133, 1051 (2020)