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Chemodex
Stigmasterol
129
CHF
CHF 129.00
In stock
CDX-S0267-G0055 gCHF 129.00
CDX-S0267-G01010 gCHF 231.00
CDX-S0267-G02525 gCHF 530.00
| Product Details | |
|---|---|
| Synonyms | 3β-Hydroxy-24-ethyl-5,22-cholestadiene; 5,22-Stigmastadien-3β-ol; Stigmasterin; Phytosterol; β-Stigmasterol; Serposterol; Wulzen anti-stiffness Factor; NSC8095 |
| Product Type | Chemical |
| Properties | |
| Formula |
C29H48O |
| MW | 412.69 |
| CAS | 83-48-7 |
| RTECS | WJ2447500 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in ethanol (20mg/ml), DMF (1mg/ml) or chloroform (50 mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | HCXVJBMSMIARIN-PHZDYDNGSA-N |
| Smiles | O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)/C=C/[C@@H](CC)C(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Stigmasterol is a phytosterol with chemical structure similar to cholesterol and anti-hypercholestrolemic activity. It exhibits anticancer, anti-inflammatory, antioxidant, antidiabetic, neuroprotective and immune-modulating properties. Stigmasterol exhibits antitumor effects in cancer cells mediated via inhibition of cell migration, cell cycle arrest, apoptosis/autophagy induction and angiogenesis inhibition. Stigmasterol is a potent in vitro antagonist of FXR (farnesoid X receptor), a DNA polymerase β inhibitor and targets the GLUT4 glucose transporter. It has anti-osteoarthritic effects, by decreasing the expression of matrix metalloproteinases. Stigmasterol shows acetylcholinesterase inhibitory activity and also enriched glutamatergic synapses in cultures of brain neurons. It also has been shown to have antitrypanasomal and insecticidal activity and has been used as an adjuvant for beta lactam antibiotics against beta-lactamase positive clinical isolates. Stigmasterol is also used as a precursor for synthetic progesterone and vitamin D3 and is an intermediate in the biosynthesis of androgens, estrogens and corticoids.
Product References
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