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Chemodex
Spinosyn A
197
CHF
CHF 197.00
In stock
CDX-S0293-M100100 mgCHF 197.00
CDX-S0293-G0011 gCHF 1'507.00
| Product Details | |
|---|---|
| Synonyms | A-83543A; Lepicidin A |
| Product Type | Chemical |
| Properties | |
| Formula |
C41H65NO10 |
| MW | 731.95 |
| CAS | 131929-60-7 |
| Source/Host Chemicals | Microbial |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White powder. |
| Solubility | Soluble in DMSO (4mg/ml), DMF (at least 30mg/ml), chloroform (at least 80mg/ml), ethanol or methanol (both at least 50mg/ml). Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | SRJQTHAZUNRMPR-IRXCAFTDSA-N |
| Smiles | O=C(C[C@]1([H])C2=C[C@]3([H])[C@]1([H])C=C[C@@]4([H])[C@@]3([H])C[C@H](O[C@]5([H])O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]5OC)C4)O[C@@H](CC)CCC[C@H](O[C@]6([H])O[C@H](C)[C@@H](N(C)C)CC6)[C@@H](C)C2=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Spinosyn A is a naturally-occurring macrocyclic lactone that is a potent insecticide. It is the main component of Spinosad working as a larvicide but also has activity on adult insects and eggs. It is active on Lepdioptera, Thysanoptera, Hymenoptera, Diptera and Coleoptera. It acts as an agonist of insect nicotinic acetylcholinesterase receptors (nAChRs), which differ both structurally and functionally from nAChRs in vertebrates. As a result, it has low affinity for vertebrate nAChRs and has limited adverse effects in those animals. This agent can be used as a reference compound.
Product References
(1) L.C. Creemer, et al.; J. Antibiot. 53, 171 (2000) | (2) D.J. Mergott, et al.; PNAS 101, 11955 (2004) | (3) S.O. Duke, et al.; Toxins 2, 1943 (2010) | (4) D.T. Vo, et al.; J. Vet. Pharmacol. Ther. 33, 315 (2010) | (5) T.S. Amaral, et al.; Braz. J. Biol. 72, 299 (2012)