Sancycline

Specifications / Handling

More Information
Product Details
Synonyms	6-Demethyl-6-deoxytetracycline; Bonomycin; Norcycline; GS 2147
Product Type	Chemical
Properties
Formula	C₂₁H₂₂N₂O₇
MW	414.4
CAS	808-26-4
Purity Chemicals	≥98% (HPLC)
Appearance	Yellow to green powder.
Solubility	Soluble in DMSO.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	XDVCLKFLRAWGIT-ADOAZJKMSA-N
Smiles	OC1=C2C(C[C@]3([H])C(C2=O)=C(O)[C@@]4(O)[C@@]([C@H](N(C)C)C(O)=C(C(N)=O)C4=O)([H])C3)=CC=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.

Product References

(1) J.R.D. McCormick, et al.; JACS 82, 3381 (1960) | (2) R.T. Testa, et al.; Antimicrob. Agents Chemother. 37, 2270 (1993) | (3) H.M. Wexler, et al.; Antimicrob. Agents Chemother. 38, 2513 (1994)

Call	+41 61 926 6040
Fax	+41 61 926 6049