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Chemodex
Tetracaine hydrochloride
41
CHF
CHF 41.00
In stock
CDX-T0453-G0055 gCHF 41.00
CDX-T0453-G02525 gCHF 75.00
CDX-T0453-G05050 gCHF 129.00
| Product Details | |
|---|---|
| Synonyms | 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester; Amethocaine hydrochloride |
| Product Type | Chemical |
| Properties | |
| Formula | C15H24N2O2 . HCl |
| MW | 264.4 . 36.5 |
| CAS | 136-47-0 |
| RTECS | DG4900000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥99% (TLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water (40mg/ml), DMSO (40mg/ml) or ethanol (20mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | PPWHTZKZQNXVAE-UHFFFAOYSA-N |
| Smiles | CCCCNC1=CC=C(C(OCCN(C)C)=O)C=C1.Cl |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at RT. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Tetracaine is a potent local anaesthetic and a channel function allosteric inhibitor that blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely. inhibitor of voltage-gated sodium channels such as NaV1.4 and NaV1.8. Shown also to reversibly block nicotinic acetylcholine (ACh) receptors (nAChRs).
Product References
(1) S. Hishinuma & M.K. Uchida; Br. J. Pharmacol. 103, 1393 (1991) | (2) L. Desmedt, et al.; J. Gen. Physiol. 101, 103 (1993) | (3) E. Jaimovich & E. Rojas; Cell Calcium. 15, 356 (1994) | (4) S. Gyoerke, et al.; J. Physiol. 500, 297 (1997) | (5) C.L. Overend, et al.; J. Physiol. 502, 471 (1997) | (6) D. Mears, et al.; Cell Calcium 25, 59 (1999) | (7) R. Cobo, et al.; Front. Mol. Neurosci. 11, 193 (2018)