Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Chemodex
Tetracaine
61
CHF
CHF 61.00
In stock
CDX-T0454-G0055 gCHF 61.00
CDX-T0454-G02525 gCHF 115.00
CDX-T0454-G05050 gCHF 197.00
| Product Details | |
|---|---|
| Synonyms | 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester |
| Product Type | Chemical |
| Properties | |
| Formula | C15H24N2O |
| MW | 264.36 |
| CAS | 94-24-6 |
| RTECS | DG4725000 |
| Source/Host Chemicals | Synthetic |
| Purity Chemicals | ≥98% (TLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO or methanol. Almost insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | GKCBAIGFKIBETG-UHFFFAOYSA-N |
| Smiles | CCCCNC1=CC=C(C(OCCN(C)C)=O)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Tetracaine is a potent local anaesthetic and a channel function allosteric inhibitor that blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely. inhibitor of voltage-gated sodium channels such as NaV1.4 and NaV1.8. Shown also to reversibly block nicotinic acetylcholine (ACh) receptors (nAChRs).
Product References
(1) S. Hishinuma & M.K. Uchida; Br. J. Pharmacol. 103, 1393 (1991) | (2) L. Desmedt, et al.; J. Gen. Physiol. 101, 103 (1993) | (3) E. Jaimovich & E. Rojas; Cell Calcium. 15, 356 (1994) | (4) S. Gyoerke, et al.; J. Physiol. 500, 297 (1997) | (5) C.L. Overend, et al.; J. Physiol. 502, 471 (1997) | (6) D. Mears, et al.; Cell Calcium 25, 59 (1999) | (7) R. Cobo, et al.; Front. Mol. Neurosci. 11, 193 (2018)