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Chemodex
Vincristine sulfate
162
CHF
CHF 162.00
In stock
CDX-V0014-M02525 mgCHF 162.00
CDX-V0014-M05050 mgCHF 264.00
| Product Details | |
|---|---|
| Synonyms | VCR; 22-Oxovincaleukoblastine; NSC 67574; Oncovin; Lilly 37231; Leucristine; Leurocristine; LS-228 |
| Product Type | Chemical |
| Properties | |
| Formula |
C46H56N4O10 . H2SO4 |
| MW | 923.04 |
| CAS | 2068-78-2 |
| RTECS | OH6340000 |
| Source/Host Chemicals | Plant |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in water (50mg/ml) or DMSO (5mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | AQTQHPDCURKLKT-JKDPCDLQSA-N |
| Smiles | O=S(O)(O)=O.O[C@@]1(C(OC)=O)[C@]2([H])N(C([H])=O)C3=C(C=C([C@@](C(OC)=O)(C[C@@H](C[C@]4(CC)O)C[N@@](C4)CC5)C6=C5C(C=CC=C7)=C7N6)C(OC)=C3)[C@]28[C@@]([C@](C=CC9)(CC)[C@H]1OC(C)=O)([H])N9CC8 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Vincristine is an antimitotic vinca alkaloid isolated from Vinca Rosea. It irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization. It is a anticancer agent and arrests cell cycle in G2/M-phase by blocking mitotic spindle formation. Vincristine triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression and induces apoptosis and autophagy in several tumor cell lines. It inhibits VEGF production in leukemia cell lines. Vincristine has some immunosuppressant effect. Vincristine may also interfere with amino acid, cyclic AMP, and glutathione metabolism, calmodulin-dependent Ca2+-transport, cellular respiration and nucleic acid and lipid biosynthesis. Vincristine inhibits monoamine oxidase (MAO), induces of IL-1β production and activates the NLRP3-inflammasome mediated processing of IL-1β.
Product References
(1) A.C. Aisenberg; Nature 200, 484 (1963) | (2) M.A. Jordan, et al.; Cancer Res. 45, 2741 (1985) | (3) J.K. Son, et al.; J. Med. Chem. 33, 1845 (1990) | (4) B.V. Harmon, et al.; Cell Prolif. 25, 523 (1992) | (5) S. Lobert, et al.; Biochemistry 35, 6806 (1996) | (6) E. Hamel; Med. Res. Rev. 16, 207 (1996) | (7) M.V. Blagosklonny, et al.; Cancer Res. 57, 130 (1997) | (8) A. Jordan, et al.; Med. Res. Rev. 18, 259 (1998) (Review) | (9) L.G. Wang; Cancer Chemother. Pharmacol. 44, 355 (1999) (Review) | (10) E. Groninger, et al.; Br. J. Haematol. 111, 875 (2000) | (11) Z. Zhan, et al.; Autophagy 8, 109 (2012) | (12) R. Mackeh, et al.; J. Cell Sci. 126, 1071 (2013) (Review) | (13) J. Wong, et al.; Cancer Biol. Ther. 15, 1395 (2014)