IL-4 (human) (rec.) (His)

CHF 210.00
In stock
CHI-HR-20004-C01010 µgCHF 210.00
CHI-HR-20004-C05050 µgCHF 630.00
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Product Details
Synonyms Interleukin-4; B Cell Stimulatory Factor 1; BSF-1
Product Type Protein
Properties
Source/Host E. coli
Sequence Human IL-4 (aa 25-153) is fused at the C-terminus to a His-tag.
Crossreactivity Human
Purity ≥98% (SDS-PAGE)
Endotoxin Content <0.1EU/μg protein (LAL test; Lonza).
Reconstitution Reconstituted in sterile H2O not less than 100μg/ml, which can then be further diluted in other aqueous solutions.
Formulation Lyophilized from 0.2μm-filtered solution in PBS (pH 7.4).
Other Product Data NCBI reference NP_000580.1: IL-4 (human)
Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2 cells. These cells tends to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-γ, and lymphotoxin (TNF-β). In addition, mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunoglobulin class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. IL-4 promotes survival, growth, and differentiation of both T and B lymphocytes, mast cells and endothelial cells. In addition, IL-4 inhibits the production of TNF, IL-1, and IL-6 by macrophages.

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