IL-2 (human) (rec.) (untagged)

CHF 180.00
In stock
CHI-HR-20602-C01010 µgCHF 180.00
CHI-HR-20602-C05050 µgCHF 480.00
NEW
More Information
Product Details
Synonyms Interleukin-2; Aldesleukin
Product Type Protein
Properties
Source/Host E. coli
Sequence

The extracellular domain of human IL-2 (aa 21-153) with a N-terminal Met.

Crossreactivity Human
Biological Activity

Measured in a cell proliferation assay using CTLL2 cells. The ED50 for this effect is typically 0.35-1.4ng/ml.

MW ~14kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg protein (LAL test; Lonza).
Reconstitution Reconstitute 10µg vial with 100 µl sterile water to a concentration of 0.1mg/ml.
Reconstitute 50µg vial with 100 µl sterile water to a concentration of 0.5mg/ml.
Further dilute in other aqueous solutions.
Formulation Lyophilized from sterile 0.1% TFA, 70% acetonitrile.
Other Product Data

NCBI reference NP_000577.2: IL-2 (human)

Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -80°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-γ and TNF-α and -β. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.

© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.