B7-H4 (mouse):Fc (mouse) (rec.)

CHF 480.00
In stock
CHI-MF-110B7H4-C100100 µgCHF 480.00
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Product Details
Synonyms V-set Domain-containing T Cell Activation Inhibitor 1; VTCN1; B7h.5; Immune Costimulatory Protein B7-H4; T Cell Costimulatory Molecule B7x; Protein B7S1
Product Type Protein
Properties
Source/Host CHO cells
Sequence

The extracellular domain of mouse B7-H4 (aa 29-258) is fused to the N-terminus of the Fc region of mouse IgG2a.

Crossreactivity Mouse
Biological Activity

Measured by its ablility to inhibit anti-CD3-induced proliferation of stimulated mouse T cells.

Purity ≥98% (SDS-PAGE)
Endotoxin Content <0.06EU/μg protein (LAL test; Lonza).
Reconstitution Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.
Formulation Lyophilized from 0.2μm-filtered solution in PBS.
Protein Negative Control

Fc (mouse) IgG2a Control (rec.)

Other Product Data

NCBI reference NP_848709.2: B7-H4 (mouse)

Declaration Manufactured by Chimerigen.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.

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