eTOPIX_Latest Additions - Small Molecules for Research - October 2022 – Sent on 24 October 2022

Collinolactone (Prod. No. BVT-0480) shows anti-neurodegenerative and neuroprotective effects by reducing intracellular oxidative stress. It has potential Amyloid β-disaggregating activity.

LIT: Structure of cyclodecatriene collinolactone, its biosynthesis, and semisynthetic analogues: effects of monoastral phenotype and protection from intracellular oxidative stress: J.C. Schmid, et al.; Angew. Chem. Int. Ed. 60, 23212 (2021) | Rhizolutin, a novel 7/10/6-tricyclic dilactone, dissociates misfolded protein aggregates and reduces apoptosis/inflammation associated with Alzheimer's Disease: Y. Kwon, et al.; Angew. Chem. Int. Ed. 59, 22994 (2020)

Lac-Phe (Prod. No. AG-CR1-3545) is an exercise-inducible metabolite, also called exerkine, that suppresses feeding and obesity. Lac-Phe is increased heavily with exercise in mammals and acts to reduce food intake and potentially decrease overall body weight and fat mass.

LIT: An exercise-inducible metabolite that suppresses feeding and obesity: V.L. Li, et al.; Nature 606, 785 (2022)

α-Galactosylceramide (Prod. No. AG-CN2-0013) is a potent stimulator of natural killer T (NKT) cells. It is a specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells.


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α-Galactosylceramide (dansylated)     

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Selected Small Molecules         From the Manufacturer!
  

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