anti-Polyethylene Glycol (methoxy group), Rabbit Monoclonal (RM105)

Polyethylene glycol (PEG) is a nonbiodegradable hydrophilic polymer widely used in biomedical applications. It has good biocompatibility, is nonimmunogenic and is resistant to protein adsorption. It helps in the purification and crystal growth of proteins and nucleic acids. PEGylation is the act of covalently coupling a PEG structure to another larger molecule, for example, a therapeutic protein, which is then referred to as a PEGylated protein. The covalent attachment of PEG (PEGylation) is commonly used to modify a variety of proteins and drugs. Some of the therapeutical benefits of PEGylated molecules include increased bioavailability, increased blood circulation of the drug, optimized pharmacokinetics, decreased immunogenicity and decreased frequency of administration. Additional benefits of PEGylated molecules include decelerated renal excretion, improved stability towards proteolysis, increased solubility of the biopharmaceutical in aqueous solutions, increased hydrodynamic radius, reduced immunogenicity and proteolytic cleavage.