RevMab

IgG4 (human) Matched Antibody Pair

CHF 629.00
In stock
REV-31-1022-MK-KI011 SetCHF 629.00
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Product Details
Synonyms Immunoglobulin G4
Product Type Set
Properties
Application Set Quantitative ELISA
Specificity The antibody pair detects only human IgG4. It does not react to monkey (Cyno or Rhesus) IgG, mouse IgG, rat IgG, or goat IgG. There is no cross reactivity to any other immunoglobulins or IgG subclasses.
Crossreactivity Human
Quantity ELISA:
Capture Antibody 50ng/well - 200ng/well
Detection Antibody 0.1ug/mL - 0.5ug/mL
Sample Type Serum
Assay Type Sandwich
Kit Contains 1) Capture Antibody: Anti-Human IgG4 Rabbit Monoclonal antibody, clone RM120, 100 ug at 1.0 mg/ml in 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
2) Detection Antibody: Biotin Anti-Human Ig Light Chain Rabbit Monoclonal Antibody, Clone RM129, 25 ug at 1.0 mg/ml in 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
3) 10X Sample Diluent: Added to the tested sample to reduce non-specific background and noise
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by RevMab Biosciences.
Accession Number P01861
Shipping and Handling
Shipping BLUE ICE
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
Manual No
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

The Human IgG4 Matched Antibody Pairs is specific to Human IgG4 and has been demonstrated through ELISA to not recognize (cross) IgG from Non-Human Primate species (Rhesus and Cynomologus macaques), nor does the matched pair recognize mouse, rat or goat immunoglobulin. The kit can be used for the detection of therapeutic antibodies from samples obtained from experimental animals to provide accurate pharmacokinetic (PK) data.
IgG (Immunoglobulin G) is the most abundant Ig isotype in serum and makes up approximately 75% of all serum Immunoglobulins. In humans, there are four subclasses of IgG with highest serum concentrations of IgG1 followed by IgG2, IgG3 and IgG4. The IgG molecule consists of two heavy and two lights chains (κ or λ) resulting in a molecule with two arms for antigen binding. High levels of IgG antibodies are induced following the initial IgM response in a typical immune response to antigens. Because of its relative abundance and excellent specificity toward antigens, IgG is the principle antibody used in immunological research and clinical diagnostics. Clinically, measured IgG antibody levels are generally considered to be indicative of an individual's immune status to particular pathogens.

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