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RevMab
IgE (human) Matched Antibody Pair
629
CHF
CHF 629.00
In stock
REV-31-1024-MK-KI011 SetCHF 629.00
Figure 1: Sandwich ELISA using RM122 as the capture antibody (100ng/well)
| Product Details | |
|---|---|
| Synonyms | Immunoglobulin E |
| Product Type | Set |
| Properties | |
| Application Set | Quantitative ELISA |
| Specificity | The antibody pair detects only human IgE. It does not react to monkey (Cyno or Rhesus) IgG, mouse IgG, rat IgG, or goat IgG. There is no cross reactivity to any other immunoglobulins or IgG subclasses. |
| Crossreactivity | Human |
| Quantity |
ELISA: Capture Antibody 50ng/well - 200ng/well Detection Antibody 0.1ug/mL - 0.5ug/mL |
| Sample Type | Serum |
| Assay Type | Sandwich |
| Kit Contains |
1) Capture Antibody: Anti-Human IgE Rabbit Monoclonal antibody, clone RM122, 100 ug at 1.0 mg/mL in 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide 2) Detection Antibody: Biotin Anti-Human Ig Light Chain Rabbit Monoclonal Antibody, Clone RM129, 25 ug at 1.0 mg/mL in 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide 3) 10X Sample Diluent: Added to the tested sample to reduce non-specific background and noise |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by RevMab Biosciences. |
| Accession Number | P01854 |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| Manual | No |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
The Human IgE Matched Antibody Pairs is specific to Human IgE and has been demonstrated through ELISA. It does not cross-react to IgG from Non-Human Primate species (Rhesus and Cynomologus macaques), or mouse, rat or goat immunoglobulin. The kit can be used for the detection of therapeutic antibodies from samples obtained from experimental animals to provide accurate pharmacokinetic (PK) data.
Immunoglobulin E (IgE) is an antibody isotype that has only been found in mammals. IgE is synthesized by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4). IgE's main function is immunity to parasites such as helminths or certain protozoan parasites such as Plasmodium falciparum. IgE may have evolved as a last line of defense to protect against venoms. IgE also has an essential role in type I hypersensitivity, which manifests in various allergic diseases, such as allergic asthma, most types of sinusitis, allergic rhinitis, food allergies and atopic dermatitis. IgE also plays a pivotal role in responses to allergens, such as: anaphylactic reactions to drugs, bee stings and antigen preparations used in desensitization immunotherapy.
Immunoglobulin E (IgE) is an antibody isotype that has only been found in mammals. IgE is synthesized by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4). IgE's main function is immunity to parasites such as helminths or certain protozoan parasites such as Plasmodium falciparum. IgE may have evolved as a last line of defense to protect against venoms. IgE also has an essential role in type I hypersensitivity, which manifests in various allergic diseases, such as allergic asthma, most types of sinusitis, allergic rhinitis, food allergies and atopic dermatitis. IgE also plays a pivotal role in responses to allergens, such as: anaphylactic reactions to drugs, bee stings and antigen preparations used in desensitization immunotherapy.