RevMab

anti-AR (ARv7 Splice Variant) (human), Rabbit Monoclonal (RM7)

CHF 698.00
In stock
REV-31-1109-00-R100100 µlCHF 698.00
More Information
Product Details
Synonyms Androgen Receptor; Dihydrotestosterone Receptor; Nuclear Receptor Subfamily 3 Group C Member 4
Product Type Recombinant Antibody
Properties
Clone RM7
Isotype Rabbit IgG
Source/Host Rabbit
Immunogen/Antigen A peptide corresponding to AR splice variant 7.
Application

Immunohistochemistry (IHC): 1:500-1:1000 dilution
Immunocytochemistry (ICC): 1:100-1:1000 dilution
Western Blot (WB): 1:500-1:1000 dilution

Crossreactivity Human
Specificity

This antibody reacts to androgen receptor splice variant 7 (AR-V7). No cross reactivity with wild type androgen receptor.

Purity Protein A purified.
Purity Detail Protein A affinity purified from an animal origin-free culture supernatant.
Concentration N/A
Formulation Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Isotype Negative Control

Rabbit IgG

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Accession Number P10275
Declaration Manufactured by RevMab Biosciences.
Shipping and Handling
Shipping BLUE ICE
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS). The AR3 or ARv7 isoform, which lacks the typical ligand binding domain, is created through the alternative splicing of cryptic exons. ARv7 is frequently expressed in castration-resistant prostate cancer (CRPC) and while dependent on the activity of the full-length androgen receptor (AR-FL), ARv7 can activate a completely distinct transcriptional program.

Product References
  1. Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer: A. Sharp, et al.; J. Clin. Invest. 129, 192 (2019)
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