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RevMab
anti-Phospho-Rsk1 (Thr359/Ser363) (human), Rabbit Monoclonal (RM233)
459
CHF
CHF 459.00
In stock
REV-31-1117-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human cerebral cortex tissue sections using Anti-phospho-Rsk1 (Thr359/Ser363) RM233 at a 1:200 dilution.
| Product Details | |
|---|---|
| Synonyms | Ribosomal Protein S6 Kinase alpha-1; S6K-alpha-1; MAPKAPK-1a; |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM233 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A phospho-peptide corresponding to human phospho-Rsk1 (Thr359/Ser363). |
| Application |
Immunohistochemistry (IHC): 1:200-1:500 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human RSK1 only when phosphorylated at Thr359/Ser363. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q15418 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
The 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed Ser/Thr kinases characterized by two nonidentical, functional kinase domains and a carboxy-terminal docking site for extracellular signal-regulated kinases (ERKs). Several sites both within and outside of the RSK kinase domain, including Ser380, Thr359, Ser363 and Thr573, are important for kinase activation. RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and phosphoinositide-3-OH kinase (PI3K) in response to many growth factors, polypeptide hormones, and neurotransmitters. Evidence from animal models suggests that RSK1 is a key regulator of glucose homeostasis and cell size.