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RevMab
anti-CD146 (human), Rabbit Monoclonal (RM249)
459
CHF
CHF 459.00
In stock
REV-31-1129-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using Anti-CD146 RM249 at a 1:400 dilution.
| Product Details | |
|---|---|
| Synonyms | Cell Surface Glycoprotein MUC18 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM249 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A synthetic peptide corresponding to the residues near C-terminus of human CD146. |
| Application |
Immunohistochemistry (IHC): 1:200-1:500 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human CD146 (Cell surface glycoprotein MUC18). This antibody may also react to mouse or rat CD146, as predicted by immunogen homology. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P43121 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
CD146 (MCAM; MUC18) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. CD146 is expressed at cell-cell junctions in all endothelial cells, and has also been observed in other normal and malignant cell types. CD146 functions as a receptor for laminin alpha 4, a matrix molecule that is broadly expressed within the vascular wall. Accordingly, CD146 is highly expressed by cells that are components of the blood vessel wall, including vascular endothelial cells, smooth muscle cells and pericytes. In addition to its recognized role as a calcium-independent cell adhesion molecule, CD146 may also act as a signal transduction molecule in the recruitment of Fyn kinase, and in the subsequent tyrosine-phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Normal melanocytes do not express CD146, but CD146 expression is positively correlated to melanoma progression.