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RevMab
anti-Calponin-1, Rabbit Monoclonal (RM262)
459
CHF
CHF 459.00
In stock
REV-31-1143-00-R100100 µlCHF 459.00
Figure 1: Immunocytochemistry of HeLa cells
| Product Details | |
|---|---|
| Synonyms | Calponin H1, Smooth Muscle |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM262 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the C-terminus of human Calponin-1. |
| Application |
Western Blot (WB): 1:1000-1:2000 dilution |
| Crossreactivity |
Human Mouse |
| Specificity |
This antibody reacts to human or mouse Calponin-1. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P51911 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Calponin-1 is a 34 kDa thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It interacts with actin, tropomyosin and calmodulin. Calponin-1 binds actin to promote and sustain polymerization. The binding of calponin to F-actin inhibits the MgATPase activity of smooth muscle myosin. The expression of Calponion-1 is specific to differentiated mature smooth muscle cells, suggesting a role in contractile functions. It is up-regulated in smooth muscle tissues during postnatal development with a higher content in phasic smooth muscle of the digestive tract. Calponin-1 has been found to be useful in differentiating benign sclerosing lesions of the breast from carcinoma. Calponin-1 positivity has also been noted in malignant myoepithelioma and pleomorphic adenoma of salivary gland origin, as well as angiomatoid malignant fibrous histiocytoma.