RevMab

anti-Calponin-1, Rabbit Monoclonal (RM262)

CHF 459.00
In stock
REV-31-1143-00-R100100 µlCHF 459.00
More Information
Product Details
Synonyms Calponin H1, Smooth Muscle
Product Type Recombinant Antibody
Properties
Clone RM262
Isotype Rabbit IgG
Source/Host Rabbit
Immunogen/Antigen A peptide corresponding to the C-terminus of human Calponin-1.
Application

Western Blot (WB): 1:1000-1:2000 dilution
Immunocytochemistry (ICC): 1:100-1:200.

Crossreactivity Human
Mouse
Specificity

This antibody reacts to human or mouse Calponin-1.

Purity Protein A purified.
Purity Detail Protein A affinity purified from an animal origin-free culture supernatant.
Concentration N/A
Formulation Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Isotype Negative Control

Rabbit IgG

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Accession Number P51911
Declaration Manufactured by RevMab Biosciences.
Shipping and Handling
Shipping BLUE ICE
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

Calponin-1 is a 34 kDa thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It interacts with actin, tropomyosin and calmodulin. Calponin-1 binds actin to promote and sustain polymerization. The binding of calponin to F-actin inhibits the MgATPase activity of smooth muscle myosin. The expression of Calponion-1 is specific to differentiated mature smooth muscle cells, suggesting a role in contractile functions. It is up-regulated in smooth muscle tissues during postnatal development with a higher content in phasic smooth muscle of the digestive tract. Calponin-1 has been found to be useful in differentiating benign sclerosing lesions of the breast from carcinoma. Calponin-1 positivity has also been noted in malignant myoepithelioma and pleomorphic adenoma of salivary gland origin, as well as angiomatoid malignant fibrous histiocytoma.

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