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RevMab
anti-JAM1 (human), Rabbit Monoclonal (RM275)
459
CHF
CHF 459.00
In stock
REV-31-1156-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human kidney tissue sections using Anti-JAM1 Rabbit Monoclonal Antibody (Clone RM275) at a 1:10000 dilution.
| Product Details | |
|---|---|
| Synonyms | Junctional Adhesion Molecule 1 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM275 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the N-terminus of human human JAM1 (Junctional adhesion molecule 1). |
| Application |
Immunohistochemistry (IHC): 1:2000-1:10000 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human JAM1 (Junctional adhesion molecule 1). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q9Y624 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
JAM-1 (CD321; F11R; JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. JAM-1 is a 32-41 kD glycoprotein, possessing two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail. The protein assembles at the membrane as a homodimer, and can associate laterally with other membrane proteins including integrins. JAM-1 is expressed on a variety of cell types, including leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and plays a role in mediating cell-cell contact. JAM-1 can be found in close proximity to several components of epithelial tight junctions, including ZO-1 and occludin. JAM-1 is involved in the maintenance of epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion and metastasis.