anti-Neurofilament-L (human), Rabbit Monoclonal (RM280)

Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate or 10nm diameter filaments found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Neurofilaments may also include peripherin, alpha-internexin, nestin and in some cases vimentin. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-L is the light or low molecular weight microfilament subunit (~70 kDa), NF-M the medium weight microfilament subunit (~160kDa) and NF-H is the heavy or high molecular weight microfilament subunit (~180-220 kDa), with some variation in different species. Antibodies againts the various neurofilament subunits are very useful cell type markers since the proteins are quite abundant and biochemically stable.