RevMab

anti-Cytokeratin-20 (human), Rabbit Monoclonal (RM283)

CHF 459.00
In stock
REV-31-1166-00-R100100 µlCHF 459.00
More Information
Product Details
Synonyms CK20; CK-20; Cytokeratin 20
Product Type Recombinant Antibody
Properties
Clone RM283
Isotype Rabbit IgG
Source/Host Rabbit
Immunogen/Antigen A peptide corresponding to the C-terminus of human Cytokeratin-20.
Application

Immunohistochemistry (IHC): 1:100-1:250 dilution
Western Blot (WB): 1:1000-1:2000 dilution

Crossreactivity Human
Specificity

This antibody reacts to human CK20 (Cytokeratin-20).

Purity Protein A purified.
Purity Detail Protein A affinity purified from an animal origin-free culture supernatant.
Concentration N/A
Formulation Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Isotype Negative Control

Rabbit IgG

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Accession Number P35900
Declaration Manufactured by RevMab Biosciences.
Shipping and Handling
Shipping BLUE ICE
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

Cytokeratins are keratin proteins found in the intracytoplasmic cytoskeleton of epithelial tissue (at least 20 different polypeptides). They are an important component of intermediate filaments, which help cells resist mechanical stress. Expression of these cytokeratins within epithelial cells is largely specific to particular organs or tissues. The subsets of cytokeratins which an epithelial cell expresses depends mainly on the type of epithelium, the moment in the course of terminal differentiation and the stage of development. Thus a specific cytokeratin expression profile allows the identification of epithelial cells. Furthermore, this applies also to the malignant counterparts of the epithelia, (carcinomas). Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. Cytokeratin-20 (CK20) is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa. Cytokeratin-20 is a useful marker of pancreatic and colorectal cancer. Cytokeratin-20 is also helpful in distinguishing different types of highly related carcinomas, such as renal oncocytomas from renal cell carcinomas. It is often used in combination with antibodies to Cytokeratin-7 (CK7) to distinguish different types of glandular tumour.

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