anti-Phospho-AMPA Receptor (Ser845) (human), Rabbit Monoclonal (RM296)

AMPA receptors (AMPARs) are heterotetrameric complexes composed of subunits GluR1–4, each of them conferring specific properties on the active receptor, including trafficking motifs, which is related to synaptic plasticity. These glutamate receptors are responsible for the fast, immediate postsynaptic response to glutamate release. Therefore, the receptor–channel complex, predominantly permeable for sodium and potassium ions, activates fast and shows rapid desensitization. AMPA receptors are abundant and widely distributed in the central nervous system. GluR1 (Glutamate Receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8, GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Phosphorylation of GluR1 is critical for long-term potentiation (LTP) and long-term depression (LTD) expression and the retention of memories.