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RevMab
anti-AMPK alpha-1 (human), Rabbit Monoclonal (RM301)
459
CHF
CHF 459.00
In stock
REV-31-1186-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human colon tissue section using anti-AMPK alpha-1 rabbit monoclonal antibody (clone RM301) at a 1:200 dilution.
| Product Details | |
|---|---|
| Synonyms | AMPKA1; 5'-AMP-activated Protein Kinase Catalytic Subunit alpha-1 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM301 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the residues near the C-terminus of human AMPK alpha-1. |
| Application |
Immunohistochemistry (IHC): 1:100-1:200 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human AMPK alpha-1 (AMPKA1) (5'-AMP-activated protein kinase catalytic subunit alpha-1). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q13131 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic alpha subunit and regulatory beta and gamma subunits. Each subunit exists as alternate isoforms ( alpha 1, alpha 2, beta 1, beta 2, gamma 1, gamma 2, gamma 3), with all 12 combinations able to form complexes. The catalytic alpha subunit of AMPK is activated allosterically by AMP, and by phosphorylation via the AMPK kinases LKB1 and CaMKK beta. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK’s role in metabolic regulation has implicated this serine/threonine kinase as a therapeutic target in heart disease, obesity and diabetes. 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK alpha 1) belongs to the serine/threonine protein kinase family and is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK).