Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
RevMab
anti-OX40 (human), Rabbit Monoclonal (RM313)
459
CHF
CHF 459.00
In stock
REV-31-1199-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using anti-OX40 rabbit monoclonal antibody (Clone RM313) at a 1:500 dilution.
| Product Details | |
|---|---|
| Synonyms | TNFRSF 4; Tumor Necrosis Factor Receptor Superfamily Member 4; CD134 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM313 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the C-terminus of human OX40 (CD134). |
| Application |
Immunohistochemistry (IHC): 1:200-1:500 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human OX40 (CD134). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P43489 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
OX40 receptor is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells. OX40 is a secondary co-stimulatory immune checkpoint molecule. OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40 expression can promote viral binding and renders cells permissive for viral entry, productive infection and syncytium formation. Stimulating the receptor can improve the response to a powerful virus vector and may be useful in vaccine development.