anti-CD5 (human), Rabbit Monoclonal (RM314)

CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein, also known as Leu-1, Ly-1 and T1. It is a member of the scavenger receptor superfamily found on T cells, thymocytes, B cell subsets, chronic B lymphocytic leukemia (B-Cells), peripheral blood dendritic cells and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 modulates T and B cell receptor signaling, thymocyte maturation and T-B cell interactions upon binding to ligands such as CD72. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome.