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RevMab
anti-Calretinin (human), Rabbit Monoclonal (RM324)
459
CHF
CHF 459.00
In stock
REV-31-1211-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue section using anti-Calretinin rabbit monoclonal antibody (Clone RM324) at a 1:1000 dilution.
| Product Details | |
|---|---|
| Synonyms | CALB2 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM324 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to N-terminus of human Calretinin. |
| Application |
Immunohistochemistry (IHC): 1:500-1:1000 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human Calretinin. It may also react to mouse or rat Calretinin, as predicted by immunogen homology. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P22676 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Calretinin, also known as calbindin 2 (formerly 29 kDa calbindin), is a calcium-binding protein involved in calcium signaling. It is a troponin C superfamily protein having six EF-hand structural motifs. The EF motif allows the protein to bind calcium, and function in calcium signaling, calcium buffering, modulating neuronal excitability and message targeting. Calretinin is abundantly expressed in neurons including retina and cortical interneurons. Expression was found in different neurons than of the similar vitamin D-dependent calcium-binding protein, calbindin-28kDa. Loss of expression of calretinin in hippocampal interneurons has been suggested to be relevant in temporal lobe epilepsy. Calretinin is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers.