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RevMab
anti-CD10 (human), Rabbit Monoclonal (RM337)
459
CHF
CHF 459.00
In stock
REV-31-1224-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human kidney tissue section using anti-CD10 rabbit monoclonal antibody (Clone RM337) at a 1:200 dilution.
| Product Details | |
|---|---|
| Synonyms | Neprilysin; Atriopeptidase; Common Acute Lymphocytic Leukemia Antigen; CALLA; Neutral Endopeptidase; Skin Fibroblast Elastase |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM337 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the N-terminus of human CD10. |
| Application |
Immunohistochemistry (IHC): 1:200-1:500 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to the cytoplasmic domain of human CD10. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P08473 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
CD10 (Neprilysin; Common Acute Lymphocytic Leukemia Antigen; CALLA), is a cell surface enzyme with neutral metalloendopeptidase activity which inactivates a variety of biologically active peptides. CD10 is expressed in a wide variety of tissues and is particularly abundant in kidney. It is also a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) and several other lymphomas or epithelial tumors. CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. CD10 is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin and bradykinin. Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie tooth Disease.