Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
RevMab
anti-IRF4 (human), Rabbit Monoclonal (RM352)
459
CHF
CHF 459.00
In stock
REV-31-1238-00-R100100 µlCHF 459.00
Figure 1: Immunohistochemical staining of formalin fixed and paraffin embedded human Appendix tissue section using anti-MUM1/IRF4 rabbit monoclonal antibody (Clone RM352) at a 1:800 dilution.
| Product Details | |
|---|---|
| Synonyms | MUM1; Multiple Myeloma Oncogene 1; Interferon Regulatory Factor 4 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM352 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A peptide corresponding to the C-terminus of human MUM1/IRF4. |
| Application |
Immunohistochemistry (IHC): 1:200-1:800 dilution |
| Crossreactivity | Human |
| Specificity |
This antibody reacts to human MUM1/IRF4 (Interferon regulatory factor 4). |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | N/A |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Isotype Negative Control | |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | Q15306 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
The IRF (interferon regulatory factor) family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. MUM1 (IRF4) is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma.